Symbol
Name
ID

Rasgrp1
RAS guanyl releasing protein 1
MGI:1314635

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes

Defective T cell proliferation

Decreased lymphocyte proliferation in response to mitogen

Increased circulating IgA level

Decreased circulating IgG level

Increased circulating IgG level

Increased circulating IgM level

Autoimmune hemolytic anemia

Increased proportion autoreactive unresponsive CD21-/low B cells

Abnormal CD4:CD8 ratio

Decreased proportion of CD4-positive T cells

Autoimmune thrombocytopenia

B-cell lymphoma

Splenomegaly

Hepatosplenomegaly

Disease(s) Associated with RASGRP1

immunodeficiency 64

Mouse Phenotypes

decreased T cell proliferation

decreased thymocyte number

enlarged spleen

increased spleen weight

abnormal T cell differentiation

abnormal CD4-positive T cell differentiation

abnormal CD8-positive, alpha-beta T cell differentiation

abnormal positive T cell selection

abnormal double-positive T cell morphology

increased neutrophil cell number

increased B-1b cell number

increased plasma cell number

decreased B cell number

increased B cell number

increased NK cell number

decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number

increased central memory CD4-positive, alpha-beta T cell number

increased effector memory CD4-positive, alpha-beta T cell number

increased CD4-positive, alpha-beta memory T cell number

decreased CD4-positive, alpha-beta T cell number

increased central memory CD8 positive, alpha-beta T cell number

increased effector memory CD8-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta memory T cell number

decreased CD8-positive, naive alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

decreased T cell number

decreased single-positive T cell number

increased T cell number

increased single-positive T cell number

abnormal T cell morphology

abnormal CD4-positive, alpha beta T cell morphology

abnormal immunoglobulin level

increased IgA level

increased IgE level

increased IgG1 level

increased IgG level

decreased IgM level

increased IgM level

increased immunoglobulin level

abnormal T cell physiology

Availability

Mouse Genotype

Rasgrp1^lag/Rasgrp1^lag

Rasgrp1^m1Anu/Rasgrp1^m1Anu

Rasgrp1^m1Btlr/Rasgrp1^m1Btlr

Rasgrp1^m2Btlr/Rasgrp1^m2Btlr

Rasgrp1^m3Btlr/Rasgrp1^m3Btlr

Rasgrp1^M4Btlr/Rasgrp1^M4Btlr

Rasgrp1^m5Btlr/Rasgrp1^m5Btlr

Rasgrp1^tm1.1Wz/Rasgrp1^tm1.1Wz

Rasgrp1^tm1Jstn/Rasgrp1^tm1Jstn

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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